NEO GAMETOGENESIS VIA OOCYTE REPLICATION

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For women with diminished ovarian reserve or advanced maternal age, various approaches have been attempted to increase oocyte yield for the ultimate goal of achieving a genotyped offspring. Producing haploid parthenogenetic embryos can generate haploid pseudo-blastomere (HpB) useful for reproduction or genetic testing at the pre-fertilization level. Nuclear transfer of the resulting HpB can generate sibling oocytes in women with low yield while maintaining the individual genetic information.