Endometrial receptivity: miRNAs signing in?

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Embryo implantation is complex and dependent on various factors in order to be successful. These factors include female age, embryo quality and chromosome constitution, endometrial receptivity, the female immune system status, and the embryo transfer method. Repeated implantation failure (RIF) generally is defined as the failure of a couple to conceive after the transfer of ≥10 good-quality embryos or after three in vitro fertilization (IVF) cycles. The interaction between the blastocyst and endometrium is critical for a pregnancy to be established and maintained.