Fertility Research

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The effect of early fetal losses on twin assisted-conception pregnancy outcomes Objective: To evaluate the effect of first trimester fetal losses on twin births from assisted reproductive technology (ART).Design: Historical cohort study.Setting: Clinic-based data.Patient(s): The study population included 9,036 twin pregnancies of ≥22 weeks' gestation in the 2005 Society for...
Comparison of transrectal ultrasonography and transrectal ultrasonography-guided seminal vesicle aspiration in the diagnosis of the ejaculatory duct obstruction Objective: To compare transrectal ultrasonography (TRUS) and TRUS-guided seminal vesicle aspiration in the diagnosis of ejaculatory duct obstruction (EDO).Design: A retrospective case-controlled study comparing the findings of TRUS and TRUS-guided seminal vesicle (SV) aspiration.Setting: Clinics of...
The DNA integrity of cryopreserved spermatozoa separated for use in assisted reproductive technology is unaffected by the type of cryoprotectant used but is related to the DNA integrity of the fresh separated preparation Objective: To investigate and compare seven different commercially available cryoprotectant media in terms of the DNA integrity of spermatozoa recovered after cryopreservation and separation using density gradient centrifugation (DGC).Design: A prospective clinical study.Setting: Tertiary care...
The human corpus luteum: life cycle and function in natural cycles Objective: To summarize recent advances in the understanding of the endocrine signaling pathways between the hypothalamus, pituitary, and human corpus luteum (CL); to examine the major paracrine and autocrine mechanisms and the key genes and proteins involved in CL development, function, and...
Expression and actions of transforming growth factors during human follicular development Objective: To correlate the temporal expression of transforming growth factor-α (TGF-α) and TGF-β genes in granulosa cells (GC) and thecal cells from human follicles at various developmental stages and to determine their trophic effects on GCs.Design: Reverse transcriptase–polymerase chain reaction...
Protein profiling of human endometrial tissues in the midsecretory and proliferative phases of the menstrual cycle Objective: To identify the proteins displaying differential expression in midsecretory phase endometrium as compared with proliferative phase endometrium.Design: Prospective study with two groups of women in the midsecretory or proliferative phase.Setting: Clinical research outpatient department....
Comparison of surgery alone and combined surgical-medical treatment in the management of symptomatic uterine adenomyoma Objective: To compare the efficacy of surgical-medical treatment and surgery alone in the treatment of uterine symptomatic adenomyoma.Design: Prospective nonrandomized study.Setting: Medical centers.Patient(s): One hundred sixty-five women treated with conservative adenomyomectomy.Intervention(s):...
Selective microsurgical removal of a pronucleus from tripronuclear human oocytes to restore diploidy: disregarded but valuable? Objective: To review data on the microsurgical removal of a single pronucleus from tripronuclear human oocytes and evaluate the future potential of this technique for obtaining diploid, transferable embryos.Design: Literature review.Setting: None.Patient(s): None.Intervention(s): None.Main Outcome...
Live birth sex ratios are not influenced by blastocyst-stage embryo transfer Objective: To analyze the sex ratio of infants born after blastocyst-stage transfer of embryos with normal preimplantation FISH genetic screening.Design: Retrospective cohort analysis.Setting: Large academic assisted reproductive technology center.Patient(s): Two hundred twenty-eight patients...
Ultrasonographer experience does not impact outcomes following ultrasound-guided embryo transfer Objective: To determine the effect of sonographer experience during ultrasound guided embryo transfer on pregnancy outcomes.Design: Retrospective chart review.Setting: A university-based academic practice.Patient(s): A total of 319 women who underwent in vitro fertilization and embryo transfer (IVF...