Fertility Research

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EVALUATING HUMAN EMBRYO CULTURE MEDIA PERFORMANCE USING C57BL-6N MOUSE EMBRYOS Human embryo culture media quality control is inherently challenging as it requires the use of non-human test embryos.1 Mouse embryos, most commonly of the B6D2F1 and B6C3F1 strains, are so robust that they often overestimate the success rates of in vitro fertilization. We demonstrated in a prior...
AUTOPHAGY IN THE HTR-8/SVNEO CELL OXIDATIVE STRESS MODEL IS ASSOCIATED WITH NLRP1 INFLAMMASOME ACTIVATION Based on the establishment of an in vitro model of trophoblast oxidative damage in human placental trophoblast cell HTR-8/SVneo, this study investigated whether there were activation of NLRP1 inflammasomes and excessive autophagy in oxidative stress damage. And further demonstrate whether there is...
PATIENTS’ PERCEIVED LEVEL OF COUNSELING AND EMOTIONAL SUPPORT, NOT NUMBER OF CYCLES, STRONGLY IMPACTS DECISION REGRET AFTER FAILED AUTOLOGOUS IVF IN WOMEN AGE 42 AND OVER An increasing number of women ≥42 years old choose to pursue autologous IVF (aIVF) despite low success rates in this age group. Few data exist on these patients’ reflections on their decision after aIVF.
ART OUTCOMES DURING THE COVID-19 PANDEMIC Nearly every facet of life has been altered by the ongoing COVID-19 pandemic, leading many to wonder whether these changes may have impacted ART treatments and outcomes. In addition, pandemic related stress (1), embryology laboratory contamination (2), and effects of infection on sperm (3), have...
Design and Validation of a Model for Quality Control Monitoring of Dichotomous IVF Outcomes Performing quality control for dichotomous outcomes such as pregnancy and live birth is challenging. A method for continuous assessment of outcomes using a moving average is preferred over monthly assessments of dichotomous outcomes such as pregnancy rates. However, warning and control limits for...
NON-TUBAL ECTOPIC (NTE) PREGNANCIES IN ASSISTED REPRODUCTIVE TECHNOLOGY (ART): 10-YEARS OF EXPERIENCE AT A LARGE URBAN UNIVERSITY BASED FERTILITY CENTER Non-tubal ectopic (NTE) pregnancies account for 7-10% of ectopic pregnancies, but disproportionately high mortalities.1,2 Infertility and assisted reproductive technology (ART) are risk factors, but limited data exists on NTE from fertility centers.1
DOES DOUBLE HATCHING (DH) IMPROVE IMPLANTATION AND ONGOING PREGNANCY? A retrospective review to determine if DH would improve implantation and ongoing pregnancy.
THE ASSOCIATION OF ESTROGEN/PROGESTERONE RATIO AND IVF OUTCOMES IN FROZEN EMBRYO CYCLES The number of frozen Embryo transfers (FET) in invitro fertilization cycles (IVF) cycles is increasing and has already surpassed in numbers of fresh stimulated IVF cycles. Increasing numbers of elective single ETs are also resulting in more frozen embryos available for subsequent FET cycles. Most...
SHIFTS IN ART CLINICAL PRACTICE – NAVIGATING CYCLE DEFINITIONS AND POTENTIAL IMPLICATION ON FERTILITY TREATMENT COVERAGE IN THE UNITED STATES Assisted reproductive technology (ART) is defined as all treatments which include the handling of gametes/embryos. In vitro fertilization (IVF) is most common type and at its inception, simply included ovarian stimulation to oocyte retrieval (OR), sperm insemination of oocytes and an early...
AGE-SPECIFIC BLASTULATION RATES IN EMBRYO CRYOPRESERVATION CYCLES YIELDING A CRYOPRESERVED BLASTOCYST Ovarian reserve and normal oocyte ploidy are inversely correlated to maternal age. However, the effects of ovarian aging on blastocyst conversion rates is not clearly described in the literature. Age-specific data on this topic would be useful when counseling patients after an embryo...