Fertility Research

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Trials and tribulations of in vitro fertilization after ovarian tissue transplantation In their systematic review of ovarian stimulation and assisted reproductive technology (ART) outcomes in women who have undergone ovarian tissue transplantation (OTT) (1), Andersen et al. attempt to provide a consistent overview of the current state of play, which is no easy task given the...
Another step forward toward the identification of sperm function biomarkers with a novel approach evaluating microRNA related pairs Probably every expert in the field of assisted reproduction agrees that basic sperm analysis has limited predictive value in forecasting the achievement of success in either natural or assisted conception. The need for robust biomarkers of sperm function is clearly demonstrated by the continuing...
Unexpected results from randomized clinical trials. Or are they? In a recent editorial, Chien (1) asked “How should we deal with unexpected results from randomized trials?” But why use the term “unexpected” at all? Indeed, before Ramirez et al.’s study was published in the New England Journal of Medicine (2), there was no robust evaluation of disease-free or...
Short-term relugolix treatment for fibroid-related pain: where do we go from here? Osuga et al. (1) report the results of a randomized, double-blind, placebo-controlled trial on the effect of relugolix, 40 mg/d for 12 weeks, in women with pelvic pain associated with uterine fibroids. Sixty-five women with a maximum numeric rating scale score of ≥4 during one menstrual cycle or...
Real-time indocyanine green fluorescent angiography in laparoscopic sigmoid vaginoplasty to assess perfusion of the pedicled sigmoid segment To assess the feasibility of intraoperative use of indocyanine green (ICG) fluorescent angiography in laparoscopic intestinal vaginoplasty to determine intestinal segment perfusion and viability.
Expanding our understanding of fertility preservation outcomes in transgender men As the field of transgender medicine continues to expand, interest in fertility preservation and transgender reproductive rights is garnering much needed attention. Increasing numbers of patients are presenting at younger ages for consultation, counseling, and treatment. Individual decisions in...
Microfluidics: a way to interrogate a single sperm? Microfluidics is a promising technology for male infertility (1). Currently, one of the most vexing problems in assisted reproduction is optimal gamete selection for intrauterine insemination (IUI) or in vitro fertilization (IVF). For oocyte selection, the number of eggs is limited by the outcome...
A different time for tubal surgery “An object in motion tends to remain in motion along a straight line unless acted upon by an outside force.”—Isaac Newton
Insulin resistance in polycystic ovary syndrome: concept versus cutoff Polycystic ovary syndrome (PCOS) is increasingly recognized as a metabolic disease. Although none of the Rotterdam diagnostic criteria pertain to metabolism per se, the metabolic comorbidities are clinically familiar and constitute a major focus of clinical attention from a diagnostic, prophylactic...
Noninvasive embryo assessment: how close are we? In the past decade many scientists underwent substantial efforts to investigate a noninvasive method for embryo selection in assisted reproductive technologies (ART). Several studies were trying to develop an algorithm using morphokinetic parameters for embryo selection (1), and others were focused...