Fertility Research

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Providing fertility care at the epicenter of a pandemic: lessons learned from universal screening of in vitro fertilization patients In early 2020, the COVID-19 pandemic gripped the United States, bringing with it countless uncertainties about the virus itself, its mode of transmission, and the best methods for testing and optimal treatment. The growing number of individuals infected nationally threatened the ability of...
Consistent evidence on the detrimental role of severe chronic endometritis on in vitro fertilization outcome and the reproductive improvement after antibiotic therapy: on the other hand, mild chronic endometritis appears a more intricate matter In the last decade, different studies demonstrated a detrimental impact of chronic endometritis (CE) on the success of spontaneous conception and assisted reproduction technologies, as well as an improvement in reproductive outcomes after CE cure (1, 2). Studies based on endometrial cultures and...
Older but not wiser: the impact of increasing paternal age on donor oocyte recipient success In this issue of Fertility and Sterility, McCarter et al. (1) report on a retrospective, observational, single-center cohort study of shared egg donation cycles to investigate whether increasing paternal age, defined as ≥45 years, negatively impacts pregnancy outcomes compared with paternal age of...
Health disparities of African Americans in reproductive medicine The first paper describing an association between African American race, infertility prevalence, and outcomes of fertility treatments was published more than 20 years ago, calling initial attention to differences in how infertility is experienced, diagnosed, and managed in African Americans. Since...
BRCA, breast cancer and in vitro fertilization: How should we advise our patients? Breast cancer is the most predominant malignancy in women worldwide. In 2020, 2.3 million women were diagnosed with breast cancer with 685,000 deaths globally (World Health Organization 2021; https://www.who.int). Factors that increase the risk for breast cancer include exogenous sex steroid...
You miss 100% of the shots you don’t take: time to push boundaries in fertility care of transgender people The lack of data on the effects of gender-affirming hormone therapy on future reproductive capacity is a conundrum for gender-affirming hormone providers and reproductive endocrinologists alike when faced with transgender and nonbinary (TGNB) patients desiring future genetic children. Given the...
Unmet financial burden of infertility care and the impact of state insurance mandates in the United States: analysis from a popular crowdfunding platform To examine infertility-related fund-raising campaigns on a popular crowdfunding website and to compare campaign characteristics across states with and without legislative mandates for insurance coverage for infertility-related care.
Pregnancy prediction performance of an annotation-free embryo scoring system on the basis of deep learning after single vitrified-warmed blastocyst transfer: a single-center large cohort retrospective study To analyze the performance of an annotation-free embryo scoring system on the basis of deep learning for pregnancy prediction after single vitrified blastocyst transfer (SVBT) compared with the performance of other blastocyst grading systems dependent on annotation or morphology scores.
Perseverance and the search for life On February 18, 2021, the NASA Mars 2020 mission reached a significant milestone by landing the Perseverance rover safely on the surface of Mars. Designed to search for signs of ancient life on the Red Planet and to capture samples for a future return mission to Earth, the spacecraft represents the...
Just perhaps: much ado about nothing The current trend of adopting adjuvant technologies and additional testing modalities without definitive evidence of improvement in clinical outcomes continues to accelerate. Conflicting publications regarding efficacy for procedures such as preimplantation genetic testing (PGT) and endometrial...