Fertility Research

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Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion Patients preparing to undergo gonadotoxic medical therapy, radiation therapy, or gonadectomy should be provided with prompt counseling regarding available options for fertility preservation for iatrogenic infertility. Fertility preservation can best be provided by comprehensive programs designed...
Endometrial macrophages, endometriosis, and microbiota: time to unravel the complexity of the relationship Traditionally the endometrial cavity was considered sterile. However, this concept is fundamentally changing slowly but steadily. Maintaining an ideal uterine environment is vital for embryo implantation, placentation, pregnancy development, and healthy childbirth at term. This requires integrity...
Immunologic and rheumatologic aspects of recurrent pregnancy loss: have the sirens enchanted us onto the rocks? Of the many disorders presenting to the reproductive medicine specialist, recurrent pregnancy loss (RPL; also designated as recurrent miscarriage [RM]) represents a most challenging and frustrating entity. While it is generally acknowledged that chromosomal aneuploidy of gametes and embryos is the...
Immunologic and rheumatologic causes and treatment of recurrent pregnancy loss: what is the evidence? For over three decades researchers have pursued immunological causes and treatment for recurrent pregnancy loss (RPL) (1). Despite these efforts immunological testing and treatment remains controversial. I would argue that this is because of poor stratification of diagnostic and therapeutic...
Meiotic arrest in azoospermic men: current implications of a recently reported novel technique for classification of arrest stage Azoospermic patients represent approximately 15% of all male infertility cases worldwide, with non-obstructive azoospermia (NOA) representing approximately 60% of these cases. However, our understanding of the genetic and molecular basis for these abnormalities is lacking in approximately 85% of...
Introduction Adjuncts, more often known as add-ons, are now part of the landscape of an in vitro fertilization cycle. Since the early days of in vitro fertilization, fertility services have rightly been seeking improved success rates. At present there are a multitude of choices for patients who are usually...
In vitro fertilization add-ons for the endometrium: it doesn’t add-up The probability of live birth from an in vitro fertilization (IVF) cycle is modest. Many additional treatments (add-ons) are available which promise to improve the success of IVF. This review summarizes the current evidence for common IVF add-ons which are suggested to improve endometrial...
Add-ons in the laboratory: hopeful, but not always helpful All the steps in an in vitro fertilization cycle are important but none more so than those that occur in the laboratory. To improve the chance of success, adjuncts, commonly referred to as ‘add-ons’, are offered. Yet as with other new interventions, add-ons in the laboratory require justification...
Outcome of in vitro fertilization cycles with preimplantation genetic testing for aneuploidies: let’s be honest with one another It is now 34 years since Michael Soules, former president of the American Society for Reproductive Medicine, authored an editorial, “The in vitro fertilization pregnancy rate: let’s be honest with one another” (1). In it he decried the, at that time, common practice of inflating in vitro...
Editorial Board