Fertility Research

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Preimplantation genetic testing for aneuploidy: It's déjà vu all over again! In this issue of the journal, we finally get the results of the long-awaited STAR, or Single-Embryo Transfer of Euploid Embryo, trial (1). I applaud the authors for publishing this negative trial. Since the first iteration of preimplantation genetic testing (PGT) was shown in multiple RCTs to...
Belly full of blood: a rare presentation of endometriosis Endometriosis is a chronic, benign, hormonally dependent gynecologic condition affecting 6%–10% of reproductive-age women and is one of the most prevalent diagnoses associated with chronic pelvic pain. Endometriosis is defined by the presence of endometrial glands and stroma outside of the uterine...
The influential mind and the power of emotion over Essure hysteroscopic sterilization A podcast in the National Public Radio series “Hidden Brain” entitled “Facts aren't enough: the psychology of false beliefs” discusses “confirmation bias”—an inductive reasoning error in which someone understands and recalls information in a way that confirms prior beliefs despite evidence to the...
Endometrial receptivity and implantation in women with previous failed embryo transfers: to scratch or not to scratch? Over the past 15 years, the topic of endometrial scratching in patients undergoing assisted reproductive technology (ART) has remained exciting and controversial. Randomized controlled trials (RCTs) have provided conflicting evidence regarding the benefits of this technique, and its mechanisms of...
Shrinking leiomyomas by pharmacological autophagy other than surgical removal Uterine myomas may have significant detrimental effects on menstruation and fertility. Regardless of their location within the uterus, they may reduce the chance of successful embryo implantation (clinical pregnancy) by 50% and increase the risk of pregnancy loss (1). While the negative impact of...
Would weight loss before frozen embryo transfer improve the live-birth rate for obese women with polycystic ovary syndrome? Despite the great advances in reproductive medicine, fertility treatment for patients with polycystic ovary syndrome (PCOS) is still a challenge. The most common severe complication related to in vitro fertilization (IVF) with fresh embryo transfer is ovarian hyperstimulation syndrome (OHSS)...
Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion Patients preparing to undergo gonadotoxic medical therapy, radiation therapy, or gonadectomy should be provided with prompt counseling regarding available options for fertility preservation for iatrogenic infertility. Fertility preservation can best be provided by comprehensive programs designed...
Endometrial macrophages, endometriosis, and microbiota: time to unravel the complexity of the relationship Traditionally the endometrial cavity was considered sterile. However, this concept is fundamentally changing slowly but steadily. Maintaining an ideal uterine environment is vital for embryo implantation, placentation, pregnancy development, and healthy childbirth at term. This requires integrity...
Immunologic and rheumatologic aspects of recurrent pregnancy loss: have the sirens enchanted us onto the rocks? Of the many disorders presenting to the reproductive medicine specialist, recurrent pregnancy loss (RPL; also designated as recurrent miscarriage [RM]) represents a most challenging and frustrating entity. While it is generally acknowledged that chromosomal aneuploidy of gametes and embryos is the...
Immunologic and rheumatologic causes and treatment of recurrent pregnancy loss: what is the evidence? For over three decades researchers have pursued immunological causes and treatment for recurrent pregnancy loss (RPL) (1). Despite these efforts immunological testing and treatment remains controversial. I would argue that this is because of poor stratification of diagnostic and therapeutic...