Fertility Research

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Clinical management of mosaic results from preimplantation genetic testing for aneuploidy (PGT-A) of blastocysts: a committee opinion Since the advent of preimplantation genetic testing for aneuploidy (PGT-A) in the 1990s, substantial changes in test methodology and technology now allow the detection and reporting of intermediate chromosome copy number (commonly referred to as mosaicism) for aneuploidy in a trophectoderm biopsy...
Feasibility of cryopreservation of rare sperm using a novel micro-straw method Intracytoplasmic sperm injection (ICSI) is currently the method of choice to achieve paternity for men with severe spermatogenic failure with very low or rare sperm. It is crucial to find an effective method for cryopreservation of sperm from men who have occasional sperm in the ejaculate or rare...
SOHLHs are essential for fertility regardless of gender or population Infertility is a heterogeneous disorder with a variety of complex causes, including gametogenesis dysfunction, endocrinopathies, anatomic defects, and environmental exposures. According to the World Health Organization, approximately 15% of couples are unable to conceive within 1 year of...
Luteinizing hormone–independent rise of progesterone as the physiological trigger of the ovulatory gonadotropins surge in the human The current ovarian cycle paradigm postulates that ovulation is triggered by a critically sustained elevation of estradiol. However, an in-depth look into the published data reveals considerable uncertainty about the relative roles of progesterone and estradiol in the ovulation process.This review...
Wonderfully wild müllerian anomalies The video article, “Laparoscopic resection of functional, non-communicating uterine horn in close approximation to functional hemiuterus,” highlights the clinical presentation, course, and fertility preserving treatment of a unilateral obstructed uterine horn—a rare müllerian anomaly (1). Müllerian...
Ovarian tissue cryopreservation is standard of care in prepubertal patients, but does it have to be? Turner syndrome is the most common sex chromosome abnormality in females. It affects approximately 1 in 2,500 newborn girls and is associated with accelerated follicular atresia, which results in gonadal insufficiency at a young age (1). Phenotypic variability in patients with Turner syndrome...
Male infertility and genitourinary birth defects: there is more than meets the eye Male factor infertility is a significant problem present in up to 50% of infertile couples. The relationship between male infertility and systemic disease is of significant interest, and emerging evidence suggests a relationship between male infertility and male genitourinary (GU) birth defects (...
Introduction Advances in medically assisted reproduction led to new understanding of many key facets of reproductive physiology often upending prior dogma. This series of reviews covers unexpected and thought-provoking advances in the hypothalamus and pituitary, folliculogenesis, ovulatory triggering, what...
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