Fertility Research

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One size does not fit all: a nuanced approach to surgical management of interstitial ectopic pregnancy Interstitial pregnancy represents a rare form of ectopic pregnancy, with implantation occurring in the interstitial aspect of the fallopian tube where it passes through the myometrium. Rupture at this site can be catastrophic, with up to 2% mortality (1). This necessitates clear diagnostics,...
Variant haplophasing by long-read sequencing: proof of concept in preimplantation genetic workup and an opportunity to distinguish balanced and normal embryos The use of preimplantation genetic testing (PGT) for aneuploidy has become an increasingly ubiquitous request for patients using in vitro fertilization, as are requests for embryo testing for structural rearrangements (PGT-SR) and monogenic diseases (PGT-M). Unfortunately, the two traditional...
Lending clarity via specificity to the diagnosis of chronic endometritis Chronic endometritis (CE) has been implicated in a number of pathophysiologic processes. However, its diagnosis is challenging. Multiple attempts have been made to characterize this disease, yet it remains poorly understood because of inconsistent diagnostic criteria and, thus, uncertain...
Enhanced myometrial vascularity—the time has come for individualized treatment of focal uterine pathology The suggestion of an arteriovenous malformation (AVM) of the uterus on ultrasound imaging has historically caused confusion and presented clinical challenges. Arteriovenous malformations are defined as abnormal anastomoses between arteries and veins, bypassing capillary beds and leading to focal,...
Early effects of the COVID-19 pandemic on fertility preferences in the United States: an exploratory study To explore early disparate impacts of the COVID-19 pandemic on fertility preferences
Ureaplasma parvum alters the immune tolerogenic state in placental tissue and could cause miscarriage To study the inflammatory profile and genes involved in the response to bacterial infections in women who developed spontaneous abortion in the presence of Ureaplasma parvum.
One size does not fit all: variations by ethnicity in demographic characteristics of men seeking fertility treatment across North America To compare racial differences in male fertility history and treatment.
Hysteroscopic incision of the incomplete uterine septum using 5-French scissors with marking strategies: a modified hysteroscopic technique To demonstrate an easier surgical strategy by using the marking technique for hysteroscopic incision of the uterine septum using 5-French cold scissors.
Renal agenesis-related genes are associated with Herlyn-Werner-Wunderlich syndrome To explore the genetic causes of Herlyn-Werner-Wunderlich syndrome (HWWS) using whole-exome sequencing.
The “mosaic” embryo: misconceptions and misinterpretations in preimplantation genetic testing for aneuploidy Preimplantation genetic testing for aneuploidy (PGT-A) remains one of the most controversial topics in reproductive medicine. With more than 40% of in vitro fertilization cycles in the United States reportedly involving PGT, both those in favor of and those opposed to PGT-A have significant...