Fertility Research

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In vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) is not cost effective to achieve a live birth compared to IVF alone in donor oocyte cycles The process of using donor oocyte can be costly for patients and in some cases it is not covered by insurance. For some patients, oocyte donation comes as their last resort after they have exhausted their financial limit. Optimizing every aspect of oocyte donation is important not only to improve...
The cost-effectiveness of preimplantation genetic testing for aneuploidy (PGT-A): an analysis of 153,865 SART cycles To determine the cost-effectiveness of PGT-A at cycle start for the treatment of infertility in the United States
A cost effectiveness analysis of preimplantation genetic testing for sickle cell trait couples Sickle cell disease (SCD) is a common autosomal recessive disease that results in significant morbidity and early mortality. Preimplantation genetic testing for monogenic diseases (PGT-M) is the process in which embryos created via in vitro fertilization (IVF) are tested for diseases like SCD;...
Transferring selected embryos, after PGT-A diagnosed as “abnormal,” where patients were refused such transfers at their original IVF centers To report outcomes of IVF cycles in which, by PGT-A “abnormal,” embryos were transferred after such transfers had been earlier refused at the patients’ original IVF centers.
Clinical outcomes of single embryo transfer with mosaic embryo: high-grade mosaic or low-grade mosaic embryo, does it matter ? Preimplantation genetic testing (PGT-A) with the use of the high resolution next-generation sequencing (hr-NGS) that can detect mosaicism in excess of 20%. The 20-80% range as mosaic and transferred with caution, only in absence of euploid embryos. These cut-off level is an ongoing debate. Despite...
Clinical experience following PGT analysis of >138,000 consecutive embryos using a fast-seqs NGS-based assay To report our clinical experience utilizing a FAST-SeqS NGS-based PGT assay, including aneuploidy rates and outcome data.
Preimplantation genetic testing for aneuploidy (PGT-A) and technology platform: does platform influence euploid call rates and/or subsequent pregnancy outcomes? With the evolution in technology platforms for PGT-A over the past decade, benefits to genetic testing companies include increased speed and reduced expense. Whether benefits have concurrently accrued to patients in terms of pregnancy outcomes is unclear. We sought to 1) compare euploid call rates...
Previously vitrified embryos can be successfully warmed, biopsied or rebiopsied, and provide results This study aimed to evaluate whether vitrified embryos could be warmed, biopsied or rebiopsied, and provide meaningful preimplantation genetic testing for aneuploidy (PGT-A) results. The vitrified and warmed embryos include both those biopsied for the first time, as well as those biopsied for a...
Artificial intelligence: non-invasive detection of morphological features associated with abnormalities in chromosomes 21 and 16 To examine whether Artificial Intelligence (AI) algorithms and computer vision technology can non-invasively identify embryos with key morphological features associated with abnormalities of chromosome 21 and 16.
If any mosaicism is identified in the trophectoderm, there is a 26% chance of mosaicism being present in the inner cell mass; a clinical paradigm, do you transfer mosaic embryos? To determine the correlation of mosaicism identified in the trophectoderm (TE) to the rate of mosaicism within the inner cell mass (ICM).