Fertility Research

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Myomectomy associated blood transfusion risk and morbidity after surgery To evaluate blood transfusion risks and the associated 30-day postoperative morbidity after myomectomy.
Phospholipase C zeta and oocyte activation defects: moving toward the objective identification of patients eligible for artificial oocyte activation Oocyte activation deficiency (OAD) seems to be the main factor contributing to poor or total fertilization failure in assisted reproductive technology cycles. The phenomenon occurs in ∼1%–5% of intracytoplasmic sperm injection (ICSI) cycles and usually recurs. Under normal conditions, oocyte...
Quantifying the risk of blood transfusion with myomectomy As the most common benign tumor in reproductive-age women, uterine fibroids are estimated to affect up to 80% of women (1). Although the majority are asymptomatic, a large proportion of those who do experience fibroid-related symptoms report a significant negative impact on quality of life. In one...
Diminished ovarian reserve and poor response to stimulation are not reliable markers for oocyte quality in young patients Today, four decades into the history of assisted reproductive technology (ART), ovarian stimulation (OS) stands as the most effective measure ever taken to increase the yields—implantation and pregnancy rates—of ART. In the classic form of OS, physicians adjust the OS parameters by assessing the...
New findings in disorders of sex development: role of DMRT3 and OAS3 We have read with great interest the study by Tsai et al. (1) in this issue of Fertility and Sterility, where the authors indicate that DMRT3 and OAS3 are involved in human disorders of sex development (DSD) by controlling ESR1 expression. These findings were supported by the identification of...
Medical management of symptomatic endometriosis: a new weapon in the arsenal? Until recently, there were few advances over the past two decades in the options available for medical management of symptomatic endometriosis. First-line medical therapies for patients with either documented or clinically suspected endometriosis have typically included the use of continuous...
Highlighting disparities in access to care for infertile men: a call to action Historically, there has been a gap between reality and the published literature about which demographic subgroups are most affected by infertility. Most epidemiologic studies on infertility have focused on the populations of patients who are either presenting for evaluation or who have received...
It’s all about timing: is the window of implantation different for day 5 and 6 blastocysts? The frozen-thawed ET (FET) cycle is becoming the most common type of assisted reproductive technology. Between 2008 and 2016, the number of frozen nondonor cycles reported to the United States Centers for Disease Control (CDC) increased more than threefold, from 25,261 to 86,266. In contrast,...
Oil or water-based contrast for hysterosalpingography? The therapeutic potential of hysterosalpingogram (HSG) for infertility is an attractive notion because HSG is a single procedure and thus less time consuming than all standard fertility treatments. In many U.S. markets, diagnostic procedures for infertility are more commonly covered by insurance...
Out of this world: fertility investigations and the space program Reports from the manned space flights to date have not clarified or mentioned changes in number of type of spermatozoa. Testicular tissue has not been biopsied in the astronauts.—Cockett et al. (1)