Fertility Research

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Hippo signaling disruption and ovarian follicle activation in infertile patients The Hippo signaling pathway, which is important in organ size regulation, is present in organisms from the fly to mammals. Disruption of the Hippo signaling pathway leads to increased nuclear translocation of the effector Yes-associated protein (YAP), resulting in the expression of cystein-rich 61...
Finding a retained embryo after attempted embryo transfer: how does it impact outcomes? Discovering embryo retention (ER) after an initial embryo transfer (ET) has been reported as a rare but not uncommon outcome, occurring in 1% to 8% of ETs (1). Fortunately, with use of ultrasound guidance for ETs, the rate of ER has decreased (2). The impact of ER on pregnancy rates has varied,...
Balancing innovation and safety: robotic-assisted donor surgery in uterus transplantation Since the first reported birth of a healthy child from uterus transplantation (UTx) in 2015, the number of reported births from clinical trials has been steadily increasing worldwide. The ethical issues surrounding UTx are complex and continuously evolving (1). Centers performing UTx use either...
Diagnosing endometriosis in adolescents: ultrasound is a game changer Dysmenorrhea, the cardinal symptom of endometriosis in adolescents, is too often considered an unavoidable rite of passage that girls must soldier through to become a woman. The concept of primary dysmenorrhea with no anatomic cause embodies the paradigm that dysmenorrhea in adolescents is most...
Cystic fibrosis carrier screening using next generation sequencing: A cautionary tale Adoption of next generation sequencing (NGS) for carrier screening can be a double-edged sword. The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene, of which homozygosity or compound heterozygosity for pathogenic variant(s) (i.e., mutations) result in CF, appears to be well...
Cryostorage of reproductive tissues in the in vitro fertilization laboratory: a committee opinion This document is designed to assist in vitro fertility clinics in the management of cryopreserved reproductive tissues stored in cryogenic storage (cryostorage) tanks, based upon scientific principles and laboratory experience related to best practice for safe and reliable storage of cryopreserved...
Carriers of cystic fibrosis among sperm donors: complete CFTR gene analysis versus CFTR genotyping To determine the frequency of cystic fibrosis (CF) carriers among sperm donors in Spain studied through a complete analysis of the CFTR gene and to compare the results with those that would have been obtained by the 4 genotyping panels of the CFTR gene most commonly used as a carrier test in the...
Embryo retention significantly decreases clinical pregnancy rate and live birth rate: a matched retrospective cohort study To investigate the embryo retention (ER) rate in embryo transfer (ET) cycles and its effects on reproductive outcomes.
Reproducible research practices and transparency in reproductive endocrinology and infertility articles To analyse the published literature in reproductive endocrinology and infertility (REI) to examine the transparency and the use of reproducible research practices of the scientific literature and to identify possible avenues for improvement.
Subfertility is not your genetic destiny The occurrence of infertility, defined as a time to pregnancy (TTP) of ≥12 months, is common, affecting 10%–25% of couples and expected to rise as more men and women delay their childbearing years (1). These trends have put a renewed focus on research aimed at understanding the intrinsic and...