Fertility Research

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Risk of breast cancer in women treated with ovarian stimulation drugs for infertility: a systematic review and meta-analysis To evaluate the evidence addressing the association between the use of ovarian stimulation drugs and the risk of breast cancer.
Disparities in access to effective treatment for infertility in the United States: an Ethics Committee opinion In the United States, economic, racial, ethnic, geographic, and other disparities prevent access to fertility treatment and affect treatment outcomes. This opinion examines the factors that contribute to these disparities, proposes actions to address them, and replaces the document of the same name...
Disposition of unclaimed embryos: an Ethics Committee opinion Programs should create and enforce written policies addressing the designation, retention, and disposal of unclaimed embryos. In the absence of program-specific policies, it is ethically permissible for a program or facility to consider embryos to have been unclaimed if a reasonable period of time...
Evidence-based outcomes after oocyte cryopreservation for donor oocyte in vitro fertilization and planned oocyte cryopreservation: a guideline To provide evidence-based recommendations to practicing physicians and others regarding the efficacy of oocyte cryopreservation (OC) for donor oocyte in vitro fertilization and planned OC.
Human embryo genetic editing: hope or pipe dream? Like many other technological developments in reproductive medicine, human embryo genetic editing has generated considerable hope and excitement, although it has also provoked great apprehension. The excitement and hope rooted in this technology are understandable. Genome editing tools, such as...
Fibroid stiffness: a cellular modulator of progesterone receptor signaling Fibroids are characterized by the accumulation of extracellular matrix (ECM) and overexpression of collagens, giving these tumors their firm characteristics (1). This stiffness alters mechanotransduction, defined as a mechanism by which cells convert mechanical stimuli into biochemical signals. In...
The evolution of Fertility and Sterility The inaugural issue of Fertility and Sterility was published in 1950. Since the first issue, many of the astounding changes in the field of reproductive medicine have been chronicled in this journal. The pace of change is often not appreciated until one looks back for perspective. Today marks...
Mosaic embryos: hiding in plain sight Martin et al. (1) studied the morphokinetics of embryos based on their chromosomal status, either euploid, aneuploid, or mosaic. They sought not to enhance embryo selection in a clinical setting, but to understand if there are differences in the morphokinetics of embryo development when mosaicism...
Endometrial receptivity: miRNAs signing in? Embryo implantation is complex and dependent on various factors in order to be successful. These factors include female age, embryo quality and chromosome constitution, endometrial receptivity, the female immune system status, and the embryo transfer method. Repeated implantation failure (RIF)...
Antimüllerian hormone–levels not written in stone “Since ‘tis Nature's law to change, Constancy alone is strange.”John Wilmot